Sangre de grado is a tree that grows in the Amazon region of South America. The tree bark and sap are used to make medicine.
A chemical in sangre de grado known as crofelemer (SP-303) was approved as a drug by the U.S. Food and Drug Administration (FDA) in 2012.
Sangre de grado or crofelemer is used for diarrhea associated with cholera, AIDS, traveling, the bug Clostridium difficile, or treatment with antibiotics. Sangre de grado is also used for treating cancer, irritable bowel syndrome (IBS), lung infections, fever, hemorrhage, bleeding gums, wounds, broken bones, vaginal infections, painful menstrual periods, hemorrhoids, and a skin condition called eczema. Other uses include treating ulcers of the mouth, throat, stomach, or intestine.
Some people apply sangre de grado or crofelemer to the skin for herpes simplex virus (types 1 and 2). It is also applied to the skin for bug bites and skin reactions from plants.
How does it work?
Sangre de grado appears to help diarrhea by slowing down the amount of water that is lost through the intestines. It might also prevent the movement of some viruses into cells. It might also block pain signals in the nerves.
The following doses have been studied in scientific research:
- For AIDS-related diarrhea: 125 mg of crofelemer (SP-303), a chemical isolated from sangre de grado, has been taken twice daily. This same chemical in a dose of 500 mg every 6 hours for 4 days has also been used.
- For traveler’s diarrhea: 125-500 mg of crofelemer (SP-303), a chemical isolated from sangre de grado, four times daily for 2 days has been used.
- For herpes (genital and anal): Applying a specific sangre de grado ointment containing 15% crofelemer (SP-303) to herpes lesions three times daily for 21 days has been used.
Side Effects & Safety
Special Precautions & Warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking sangre de grado if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
A type of blood cancer called leukemia: Sangre de grado might make this condition worse. Avoid using sangre de grado if you have leukemia.